Technology & Research

Antimicrobial Release


How does SEAL-N-KILL protect frequently touched surfaces?

SEAL-N-KILL incorporates patented Agion Antimicrobial Technology and a patent-pending delivery system to protect surfaces from the growth of microorganisms by releasing metallic ions. SEAL-N-KILL Antimicrobial Protective Barriers are impregnated with silver and copper which are released in the form of metallic ions under the same conditions that foster the growth of microorganisms. Metallic ions have proven antimicrobial activity (see ppt presentation on Home Page (link) and Publications section (link)). They disrupt many cell functions, killing the microorganisms. As the metallic ions kill microorganisms via multiple mechanisms the microorganisms can't develop resistance to the metal actives.


How do silver and copper ions kill microbes?

Multiple killing mechanisms; including rupturing cell membrane - cells lose nutrients and water, preventing respiration, inhibiting membrane transport, cell division and reproduction and disrupting cell metabolism. Multifaceted attack prevents resistance formation.


Why use both silver and copper as antimicrobial agents and not just one?

It has also been shown that when silver treatment is combined with other antimicrobial methods such as UV light, copper ions, or oxidizers, a synergistic effect is observed, that is bacterial growth is inhibited more by treatment with silver and an additional antimicrobial method than would be expected if the inhibition effects of silver and that additional antimicrobial method were summed (Silvestry-Rodriguez et al., 2007). This is why our product is so effective combining silver and copper. They work synergistically together.


Slow-release of silver over time using a zeolite to bind and hold the silver ion is most effective.

Silver zeolite is also a commonly used form of antibacterial silver. Zeolite is a porous matrix of sodium aluminosilicate that can bind a large amount of silver and copper ions in its micropores (Monteiro et al., 2009). The zeolite and timed release of antimicrobial metal ions is at the heart of patented Agion Antimicrobial Technology. Silver and copper ions are released from the zeolite matrix by exchange with other cations in solution and the amount released is proportional to the concentration of other cations in the solution (Breck, 1974 as cited in Kawahara et al., 2000). Kawahara et al., (2000) ran experiments to test the antimicrobial properties of silver zeolite in anaerobic conditions. Minimum inhibitory concentration (MIC) assays were performed using silver zeolite, and it was found that depending on the species tested, the minimum inhibitory concentrations of silver zeolite ranged from 256 to 2048 µg/ml, which corresponded to a range of 4.8 to 38.4 µg/ml of Ag+. Because zeolite is already used in some toothpastes as a polishing material and the lack of silver toxicity to humans at concentrations such as those found in the MIC assays, the authors believed that silver zeolite would be a good compound to incorporate into dental materials, even those used in anaerobic conditions such as in periodontal pockets (Kawahara et al., 2000). Ionic silver is used in catheters, wound dressings, surgical masks and other medical products.

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